Age-Related Skin Inflammation in A 2,4-Dintrochlorobenzene-Induced Atopic Dermatitis Mouse Model

Abstract

One of the most affected aspects of the aging process is immunity, with age-related immune system decline beingresponsible for an increase in susceptibility to infectious diseases and cancer risk. On the other hand, the agingprocess is accompanied with low-grade pro-inflammatory status. This condition involves a persistent rise in cytokinelevels that can activate both innate and adaptive immune systems. Finally, despite the fact that immunologicalresponses to antigenic stimulations decrease with age, the incidence and prevalence of many common autoimmunediseases increase in the elderly population. Overall, the co-existence of a prolonged, low-grade inflammatory statusand declining immune activity appears to be a paradoxical phenomenon. This study characterized skin inflammation inmouse dermatitis model of various ages to monitor possible changes of inflammatory responses during aging.

Keywords

• aging
• dermatitis
• immune system
• inflammation