Voltammetric determination of acyclovir using nanoporous glassy carbon electrode

Abstract

In this research project, a simple electrochemical method was presented with the easy conversion of the electrode surface into a nano-sized and porous structure. The nanoporous was deposited on the surface of glassy carbon electrode by chronoamperometric method by applying potential. The proposed electrode was used to measure acyclovir drug. Under optimal conditions a significant improvement in the electrochemical behavior of acyclovir was observed on the surface of the modified electrode compared to the unmodified electrode. The detection limit of 0.13 μM and the linear range of 1.99 to 19.6 μM were obtained for the determination of acyclovir at the surface of modified electrode using differential pulse voltammetric method in phosphate buffer. Satisfactory results were obtained in the determination of acyclovir with the modified electrode in blood serum samples.

Keywords

• voltammetry
• glassy carbon electrode
• nano porous
• acyclovir