Exploring the link between exposure to volatile organic chemicals and incidence of infertility:A cross-sectional study

Wen Zhang; Jiarong He; Fang Zhao; Jing Pan; Jiefu Wen; Lijun Jiang; Mingming Zhang

Heliyon (Jan 2025)

Exploring the link between exposure to volatile organic chemicals and incidence of infertility:A cross-sectional study

Wen Zhang,
Jiarong He,
Fang Zhao,
Jing Pan,
Jiefu Wen,
Lijun Jiang,
Mingming Zhang

Affiliations

Wen Zhang: Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Department of Nephrology, Yiyang Central Hospital affiliated, University of South China, Yiyang, Hunan, PR China
Jiarong He: Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China
Fang Zhao: Department of Rheumatology, The First Hospital and Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, PR China
Jing Pan: Department of Nephrology, Hengyang Central Hospital, University of South China, Hengyang, Hunan, PR China
Jiefu Wen: Department of Nephrology, Yiyang Central Hospital affiliated, University of South China, Yiyang, Hunan, PR China
Lijun Jiang: Department of Orthopedics, Yiyang Central Hospital affiliated, University of South China, Yiyang, Hunan, PR China
Mingming Zhang: Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China; Corresponding author.

Journal volume & issue: Vol. 11, no. 1
p. e40902

Abstract

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Abstact: Background: Growing evidence suggests that environmental pollutants exert a detrimental impact on female fertility. Among these pollutants, volatile organic compounds (VOCs), easily encountered in the environment, have garnered significant attention as prevalent airborne contaminants. Nevertheless, a definitive consensus regarding the association between VOCs and the incidence of infertility remains elusive. Method: Conducted as a cross-sectional study, this research utilized data from three survey cycles of the NHANES program spanning from 2013 to 2018. The objective was to delve into the relationship between volatile organic compounds and the prevalence of infertility. The definition of infertility relied upon information derived from the reproductive health questionnaire. In order to comprehensively explore this relationship, various analytical models, including logistic regression, weighted quantile sum (WQS), and Bayesian kernel-machine regression (BKMR), were employed. Result: A total of 1098 participants, 120 in the infertility group and 978 in the control group, were included. All 15 volatile organic compounds showed higher concentrations in the infertility group's urine. Multivariate regression revealed that the highest AMCC (N-acetyl-S-(N-methylcarbamoyl)-L-cysteine) and CYMA (2-hydroxyethyl mercapturic acid) quartiles associated with significant infertility increases, approximately 191 % and 128 %, respectively, versus the lowest quartile (OR for AMCC = 2.91; 95%CI: 1.33, 6.37; OR for CYMA = 2.28; 95%CI: 1.01, 5.15). This emphasizes AMCC and CYMA's role in infertility, supported by WQS and BKMR studies. Inflammation mediates AMCC's impact on infertility, enhancing our understanding of volatile organic compounds and reproductive health. Conclusion: The study highlights the correlation between VOCs exposure, notably AMCC and CYMA, and infertility. It identifies inflammation as a mediating factor connecting AMCC to infertility.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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