The role of ubiquitin-specific peptidases in glioma progression

Wulong Liang; Jia Fang; Shaolong Zhou; Weihua Hu; Zhuo Yang; Zian Li; Lirui Dai; Yiran Tao; Xudong Fu; Xinjun Wang

Biomedicine & Pharmacotherapy (Feb 2022)

The role of ubiquitin-specific peptidases in glioma progression

Wulong Liang,
Jia Fang,
Shaolong Zhou,
Weihua Hu,
Zhuo Yang,
Zian Li,
Lirui Dai,
Yiran Tao,
Xudong Fu,
Xinjun Wang

Affiliations

Wulong Liang: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China
Jia Fang: Clinical Research Service Center, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, Henan 450000, PR China
Shaolong Zhou: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China
Weihua Hu: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China
Zhuo Yang: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China
Zian Li: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China
Lirui Dai: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China
Yiran Tao: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China
Xudong Fu: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China; Corresponding authors at: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China.
Xinjun Wang: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China; Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, PR China; Corresponding authors at: Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PR China.

Journal volume & issue: Vol. 146
p. 112585

Abstract

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The balance between ubiquitination and deubiquitination is crucial for protein stability, function and location under physiological conditions. Dysregulation of E1/E2/E3 ligases or deubiquitinases (DUBs) results in malfunction of the ubiquitin system and is involved in many diseases. Increasing reports have indicated that ubiquitin-specific peptidases (USPs) play a part in the progression of many kinds of cancers and could be good targets for anticancer treatment. Glioma is the most common malignant tumor in the central nervous system. Clinical treatment for high-grade glioma is unsatisfactory thus far. Multiple USPs are dysregulated in glioma and have the potential to be therapeutic targets. In this review, we collected studies on the roles of USPs in glioma progression and summarized the mechanisms of USPs in glioma tumorigenesis, malignancy and chemoradiotherapy resistance.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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