Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Javad Alizadeh; Mahboubeh Kavoosi; Navjit Singh; Shahrokh Lorzadeh; Amir Ravandi; Biniam Kidane; Naseer Ahmed; Fatima Mraiche; Michael R. Mowat; Saeid Ghavami

doi:10.3390/cancers15082195

Cancers (Apr 2023)

Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer

Javad Alizadeh,
Mahboubeh Kavoosi,
Navjit Singh,
Shahrokh Lorzadeh,
Amir Ravandi,
Biniam Kidane,
Naseer Ahmed,
Fatima Mraiche,
Michael R. Mowat,
Saeid Ghavami

Affiliations

Javad Alizadeh: Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
Mahboubeh Kavoosi: Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
Navjit Singh: Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
Shahrokh Lorzadeh: Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada
Amir Ravandi: Department of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Institute of Cardiovascular Sciences, Albrechtsen Research Centre, St. Boniface Hospital, Winnipeg, MB R2H 2A6, Canada
Biniam Kidane: Section of Thoracic Surgery, Department of Surgery, Health Sciences Centre, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3T 6C5, Canada
Naseer Ahmed: CancerCare Manitoba Research Institute, Winnipeg, MB R3E 0V9, Canada
Fatima Mraiche: College of Pharmacy, QU Health, Qatar University, Doha 2713, Qatar
Michael R. Mowat: CancerCare Manitoba Research Institute, Winnipeg, MB R3E 0V9, Canada
Saeid Ghavami: Department of Human Anatomy and Cell Science, College of Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada

DOI: https://doi.org/10.3390/cancers15082195
Journal volume & issue: Vol. 15, no. 8
p. 2195

Abstract

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Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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Abstract

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