Nature Communications (Jul 2021)
Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma
- Yun-Fan Sun,
- Liang Wu,
- Shi-Ping Liu,
- Miao-Miao Jiang,
- Bo Hu,
- Kai-Qian Zhou,
- Wei Guo,
- Yang Xu,
- Yu Zhong,
- Xiao-Rui Zhou,
- Ze-Fan Zhang,
- Geng Liu,
- Sheng Liu,
- Ying-Hong Shi,
- Yuan Ji,
- Min Du,
- Nan-Nan Li,
- Gui-Bo Li,
- Zhi-Kun Zhao,
- Xiao-Yun Huang,
- Li-Qin Xu,
- Qi-Chao Yu,
- David H. Peng,
- Shuang-Jian Qiu,
- Hui-Chuan Sun,
- Michael Dean,
- Xiang-Dong Wang,
- Wen-Yuan Chung,
- Ashley R. Dennison,
- Jian Zhou,
- Yong Hou,
- Jia Fan,
- Xin-Rong Yang
Affiliations
- Yun-Fan Sun
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Liang Wu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Shi-Ping Liu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Miao-Miao Jiang
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Bo Hu
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Kai-Qian Zhou
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Wei Guo
- Department of Laboratory Medicine, Zhongshan Hospital, Fudan University
- Yang Xu
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Yu Zhong
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Xiao-Rui Zhou
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Ze-Fan Zhang
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Geng Liu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Sheng Liu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Ying-Hong Shi
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Yuan Ji
- Department of Pathology, Zhongshan Hospital, Fudan University
- Min Du
- Department of Pathology, Zhongshan Hospital, Fudan University
- Nan-Nan Li
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Gui-Bo Li
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Zhi-Kun Zhao
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Xiao-Yun Huang
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Li-Qin Xu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- Qi-Chao Yu
- BGI-Shenzhen, Shenzhen, Beishan Industrial Zone
- David H. Peng
- Dunwill Med-Tech
- Shuang-Jian Qiu
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Hui-Chuan Sun
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Michael Dean
- Laboratory of Translational Genomics, Division of Cancer Epidemiology & Genetics, National Cancer Institute Gaithersburg
- Xiang-Dong Wang
- Zhongshan Hospital Institute of Clinical Science, Shanghai Institute of Clinical Bioinformatics, Fudan University Center for Clinical Bioinformatics
- Wen-Yuan Chung
- Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust
- Ashley R. Dennison
- Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust
- Jian Zhou
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Yong Hou
- Zhong-Hua Precision Medical Center, Zhongshan Hospital, Fudan University–BGI
- Jia Fan
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- Xin-Rong Yang
- Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education
- DOI
- https://doi.org/10.1038/s41467-021-24386-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Circulating tumour cells can be useful for monitoring disease progression but how they survive in the circulatory system is unclear. Here, the authors use single-cell sequencing of circulating tumour cells from multiple vascular sites in liver cancer patients and identify genes that may help the cells survive.
