Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

Timothy J. C. Tan; Meng Yuan; Kaylee Kuzelka; Gilberto C. Padron; Jacob R. Beal; Xin Chen; Yiquan Wang; Joel Rivera-Cardona; Xueyong Zhu; Beth M. Stadtmueller; Christopher B. Brooke; Ian A. Wilson; Nicholas C. Wu

doi:10.1038/s41467-021-24123-7

Nature Communications (Jun 2021)

Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain

Timothy J. C. Tan,
Meng Yuan,
Kaylee Kuzelka,
Gilberto C. Padron,
Jacob R. Beal,
Xin Chen,
Yiquan Wang,
Joel Rivera-Cardona,
Xueyong Zhu,
Beth M. Stadtmueller,
Christopher B. Brooke,
Ian A. Wilson,
Nicholas C. Wu

Affiliations

Timothy J. C. Tan: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign
Meng Yuan: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Kaylee Kuzelka: Department of Biochemistry, University of Illinois at Urbana-Champaign
Gilberto C. Padron: Department of Biochemistry, University of Illinois at Urbana-Champaign
Jacob R. Beal: Department of Biochemistry, University of Illinois at Urbana-Champaign
Xin Chen: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign
Yiquan Wang: Department of Biochemistry, University of Illinois at Urbana-Champaign
Joel Rivera-Cardona: Department of Microbiology, University of Illinois at Urbana-Champaign
Xueyong Zhu: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Beth M. Stadtmueller: Department of Biochemistry, University of Illinois at Urbana-Champaign
Christopher B. Brooke: Department of Microbiology, University of Illinois at Urbana-Champaign
Ian A. Wilson: Department of Integrative Structural and Computational Biology, The Scripps Research Institute
Nicholas C. Wu: Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign

DOI: https://doi.org/10.1038/s41467-021-24123-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Public antibody clonotypes that recognize SARS-CoV-2 spike protein are important for protection against COVID-19. Here, the authors characterize sequence motifs in the heavy chain complementarity-determining region (CDR) H3s of two public clonotypes and their association with light chain identity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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