Synthesis of D-manno-heptulose via a cascade aldol/hemiketalization reaction

Abstract

A [4 + 3] synthesis of D-manno-heptulose is described. The cascade aldol/hemiketalization reaction of a C4 aldehyde with a C3 ketone provides the differentially protected ketoheptose building block, which can be further reacted to furnish target D-manno-heptulose.

Keywords

• aldol reaction
• cascade reaction
• D-manno-heptulose
• higher-carbon sugar
• ketoheptose