Phenopyrrolizins A and B, Two Novel Pyrrolizine Alkaloids from Marine-Derived Actinomycetes <i>Micromonospora</i> sp. HU138
Hui Zhang,
Xiaohan Ren,
Haiju Xu,
Huan Qi,
Shihua Du,
Jun Huang,
Ji Zhang,
Jidong Wang
Affiliations
Hui Zhang
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Xiaohan Ren
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Haiju Xu
Key Laboratory of Horticultural Biotechnology of Taizhou, School of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou 318020, China
Huan Qi
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Shihua Du
College of Plant Protection, Northeast Agricultural University, Harbin 150030, China
Jun Huang
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Ji Zhang
College of Plant Protection, Northeast Agricultural University, Harbin 150030, China
Jidong Wang
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China
Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B (1 and 2), were obtained from the fermentation broth of marine-derived Micromonospora sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of 1 was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that 2 could inhibit the mycelial growth of Botrytis cinerea with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.
