Strategies for Targeting Peptide-Modified Exosomes and Their Applications in the Lungs

Abstract

Min Qiu,1,2,* Jinru Zou,2,* Zheng Yang,3 Dan Yang,2 Rui Wang,1 Haie Guo1,4 1College of Veterinary Medicine, Inner Mongolia Agricultural University, Inner Mongolia, People’s Republic of China; 2College of Pharmacy, Baotou Medical College, Baotou, People’s Republic of China; 3The First Affiliated Hospital, Baotou Medical College, Baotou, People’s Republic of China; 4Agriculture, Animal Husbandry and Science and Technology Bureau of Liangcheng County, Ulanqab, Inner Mongolia, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui Wang; Haie Guo, Email [email protected]; [email protected]: Exosomes belong to a subgroup of extracellular vesicles secreted by various cells and are involved in intercellular communication and material transfer. In recent years, exosomes have been used as drug delivery carriers because of their natural origin, high stability, low immunogenicity and high engineering ability. However, achieving targeted drug delivery with exosomes remains challenging. In this paper, a phage display technology was used to screen targeted peptides, and different surface modification strategies of targeted peptide exosomes were reviewed. In addition, the application of peptide-targeted exosomes in pulmonary diseases was also summarised.Keywords: exosome, targeted peptide modification, targeted delivery, lung

Keywords

• exosome
• targeted peptide modification
• targeted delivery
• lung