Revealing the mechanism and efficacy of natural products on treating the asthma: Current insights from traditional medicine to modern drug discovery
Dionysius Subali,
Rudy Kurniawan,
Reggie Surya,
In-Seon Lee,
Sanghyun Chung,
Seok-Jae Ko,
Myunghan Moon,
Jinwon Choi,
Moon Nyeo Park,
Nurpudji Astuti Taslim,
Hardinsyah Hardinsyah,
Fahrul Nurkolis,
Bonglee Kim,
Kwan-il Kim
Affiliations
Dionysius Subali
Department of Biotechnology, Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia
Rudy Kurniawan
Diabetes Connection Care, Eka Hospital Bumi Serpong Damai, Tangerang, 15321, Indonesia
Reggie Surya
Department of Food Technology, Faculty of Engineering, Bina Nusantara University, Jakarta, 11480, Indonesia
In-Seon Lee
College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Acupuncture & Meridian Science Research Center, Kyung Hee University, Seoul, 02447, Republic of Korea
Sanghyun Chung
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Kyung Hee Myungbo Clinic of Korean Medicine, Hwaseong-si, 18466, Republic of Korea
Seok-Jae Ko
Department of Gastroenterology, College of Korean Medicine, Kyung Hee University, Seoul, 05253, Republic of Korea
Myunghan Moon
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea
Jinwon Choi
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea
Moon Nyeo Park
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea
Nurpudji Astuti Taslim
Division of Clinical Nutrition, Department of Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia
Hardinsyah Hardinsyah
Division of Applied Nutrition, Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, 16680, Indonesia
Fahrul Nurkolis
Department of Biological Sciences, Faculty of Sciences and Technology, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta, 55281, Indonesia
Bonglee Kim
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea; Corresponding author.
Kwan-il Kim
Division of Allergy, Immune and Respiratory System, Department of Internal Medicine, College of Korean Medicine, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Republic of Korea; Corresponding author.
Asthma remains a significant global health challenge, demanding innovative approaches to treatment. Traditional medicine has a rich history of using natural products to alleviate asthmatic symptoms. However, transitioning from these traditional remedies to modern drug discovery approaches has provided fresh insights into the mechanisms and effectiveness of these natural products. This study provides our comprehensive review, which examines the current state of knowledge in the treatment of asthma. It delves into the mechanisms through which natural products ameliorate asthma symptoms, and it discusses their potential in the development of novel therapeutic interventions. Our analysis reveals that natural products, traditionally employed for asthma relief, exhibit diverse mechanisms of action. These include anti-inflammatory, bronchodilatory, immunomodulatory effects, and reducing gene expression. In the context of modern drug discovery, these natural compounds serve as valuable candidates for the development of novel asthma therapies. The transition from traditional remedies to modern drug discovery represents a promising avenue for asthma treatment. Our review highlights the substantial efficacy of natural products in managing asthma symptoms, underpinned by well-defined mechanisms of action. By bridging the gap between traditional and contemporary approaches, we contribute to the growing body of knowledge in the field, emphasizing the potential of natural products in shaping the future of asthma therapy.