PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

Mohamad Moustafa Ali; Vijay Suresh Akhade; Subazini Thankaswamy Kosalai; Santhilal Subhash; Luisa Statello; Matthieu Meryet-Figuiere; Jonas Abrahamsson; Tanmoy Mondal; Chandrasekhar Kanduri

doi:10.1038/s41467-018-03265-1

Nature Communications (Feb 2018)

PAN-cancer analysis of S-phase enriched lncRNAs identifies oncogenic drivers and biomarkers

Mohamad Moustafa Ali,
Vijay Suresh Akhade,
Subazini Thankaswamy Kosalai,
Santhilal Subhash,
Luisa Statello,
Matthieu Meryet-Figuiere,
Jonas Abrahamsson,
Tanmoy Mondal,
Chandrasekhar Kanduri

Affiliations

Mohamad Moustafa Ali: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Vijay Suresh Akhade: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Subazini Thankaswamy Kosalai: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Santhilal Subhash: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Luisa Statello: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Matthieu Meryet-Figuiere: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Jonas Abrahamsson: Department of Pediatrics, Institution for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg
Tanmoy Mondal: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg
Chandrasekhar Kanduri: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg

DOI: https://doi.org/10.1038/s41467-018-03265-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 20

Abstract

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Although we know lncRNAs play a role in cancer, the identification of clinically relevant and functional lncRNAs is lacking. Here, the authors identify 633 prognostic markers, 570 S-phase cancer-associated lncRNAs, and show SCAT7 regulates FGF/FGFR and PI3K/AKT/MAPK pathways via interaction with hnRNPK/YBX1 complexes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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