Influence of dietary protein on serum phosphorous levels in peritoneal dialysis patients with different initial transport function

Abstract

Introduction This cross-sectional study investigated the influence of dietary protein intake (DPI) on serum phosphate levels in peritoneal dialysis (PD) patients and determined the DPI cutoff required to prevent hyperphosphatemia.Methods A total of 504 PD patients were categorized into fast (4 h dialysate/plasma [D/P] creatinine clearance ≥0.65) or slow ( 1.0 g/kg/d (p < 0.001). High DPI only increased the hyperphosphatemia risk in slow transporters (not in high transporters). DPI ≥1.026 g increased the hyperphosphatemia risk in those patients (area under the curve: 0.66, p = 0.001).Conclusion High DPI increases the hyperphosphatemia risk in PD patients with slower peritoneal transport function.

Keywords

• Dietary protein intake
• hyperphosphatemia
• peritoneal dialysis
• peritoneal transport function
• peritoneal phosphate clearance