Serum irisin levels increase in girls with central precocious puberty not dependent on BMI: a pilot study

Abstract

Objective: The objective of this study is to investigate the role of seru m irisin level in diagnosis of central precocious puberty (CPP) in girls and its major determinants. Methods: This study was conducted in 67 girls with CPP, 19 girls with p remature thelarche (PT) and 59 normal controls. The major determinants of irisin w ere assessed by multivariate linear regression (MLR) analysis. Propensity score matching (PSM) analysis was performed to minimize the bias that can result from BMI. A receiver operating characteristic curve was used to obtain the optimal threshold v alue of irisin. Results: The girls with CPP and PT had higher irisin levels than contro ls (P < 0.05). The optimal cutoff value of irisin levels for predicting CPP was 91. 88 ng/mL, with a sensitivity of 70.1% and a specificity of 72.9%. MLR analysis showed that BM I was a predictor of irisin (P < 0.05). Serum irisin levels remained higher in the CPP girls than the controls with adjustment for BMI (P < 0.05). Conclusions: Increased serum irisin levels with CPP suggest that irisin is involved in puberty. However, due to low sensitivity and specificity, irisin level ca n only be used as an auxiliary indicator rather than a single diagnostic indicator of CPP.

Keywords

• irisin
• central precious puberty
• premature thelarche
• diagnosis
• bmi