Emerging Infectious Diseases (Feb 2023)

Incidence and Transmission Dynamics of Bordetella pertussis Infection in Rural and Urban Communities, South Africa, 2016‒2018

  • Fahima Moosa,
  • Stefano Tempia,
  • Jackie Kleynhans,
  • Meredith McMorrow,
  • Jocelyn Moyes,
  • Mignon du Plessis,
  • Maimuna Carrim,
  • Florette K. Treurnicht,
  • Orienka Helferscee,
  • Thulisa Mkhencele,
  • Azwifarwi Mathunjwa,
  • Neil A. Martinson,
  • Kathleen Kahn,
  • Limakatso Lebina,
  • Floidy Wafawanaka,
  • Cheryl Cohen,
  • Anne von Gottberg,
  • Nicole Wolter

DOI
https://doi.org/10.3201/eid2902.221125
Journal volume & issue
Vol. 29, no. 2
pp. 294 – 303

Abstract

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We conducted 3 prospective cohort studies (2016–2018), enrolling persons from 2 communities in South Africa. Nasopharyngeal swab specimens were collected twice a week from participants. Factors associated with Bordetella pertussis incidence, episode duration, and household transmission were determined by using Poisson regression, Weibull accelerated time-failure, and logistic regression hierarchical models, respectively. Among 1,684 participants, 118 episodes of infection were detected in 107 participants (incidence 0.21, 95% CI 0.17–0.25 infections/100 person-weeks). Children 7 days infection duration. In both communities, there was high incidence of B. pertussis infection and most cases were colonized.

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