An Activatable 19F MRI Molecular Probe for Sensing and Imaging of Norepinephrine
Lingxuan Li,
Dr. Ao Li,
Yaying Lin,
Dongxia Chen,
Bilun Kang,
Dr. Hongyu Lin,
Prof. Dr. Jinhao Gao
Affiliations
Lingxuan Li
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Dr. Ao Li
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Yaying Lin
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Dongxia Chen
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Bilun Kang
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Dr. Hongyu Lin
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Prof. Dr. Jinhao Gao
The MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China
Abstract Norepinephrine (NE), acting as both a neurotransmitter and hormone, plays a significant role in regulating the action of the brain and body. Many studies have demonstrated a strong correlation between mental disorders and aberrant NE levels. Therefore, it is of urgent demand to develop in vivo analytical methods of NE for diagnostic assessment and mechanistic investigations of mental diseases. Herein, we report a 19F MRI probe (NRFP) for sensing and imaging NE, which is constructed by conjugating a gadolinium chelate to a fluorine‐containing moiety through a NE‐responsive aromatic thiocarbonate linkage. The capacity and specificity of NRFP for detecting NE is validated with in vitro detecting/imaging experiments. Furthermore, the feasibility of NRFP for visualizing NE in animals is illustrated by ex vivo and in vivo imaging experiments, demonstrating the promising potential of NRFP for selective detection and specific imaging of NE in deep tissues of living subjects.
