Fast holographic scattering compensation for deep tissue biological imaging

Molly A. May; Nicolas Barré; Kai K. Kummer; Michaela Kress; Monika Ritsch-Marte; Alexander Jesacher

doi:10.1038/s41467-021-24666-9

Nature Communications (Jul 2021)

Fast holographic scattering compensation for deep tissue biological imaging

Molly A. May,
Nicolas Barré,
Kai K. Kummer,
Michaela Kress,
Monika Ritsch-Marte,
Alexander Jesacher

Affiliations

Molly A. May: Institute of Biomedical Physics, Medical University of Innsbruck
Nicolas Barré: Institute of Biomedical Physics, Medical University of Innsbruck
Kai K. Kummer: Institute of Physiology, Medical University of Innsbruck
Michaela Kress: Institute of Physiology, Medical University of Innsbruck
Monika Ritsch-Marte: Institute of Biomedical Physics, Medical University of Innsbruck
Alexander Jesacher: Institute of Biomedical Physics, Medical University of Innsbruck

DOI: https://doi.org/10.1038/s41467-021-24666-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 8

Abstract

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Wavefront shaping is used to overcome scattering in biological tissues during imaging, but determining the compensation is slow. Here, the authors use holographic phase stepping interferometry, where new phase information is updated after each measurement, enabling fast improvement of the wavefront correction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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