Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi (Mar 2024)
Prevalence of HLA-B*5701 in People Living with HIV: A Single Center Retrospective Study
Abstract
Introduction: HLA-B*5701 has been associated with the development of hypersensitivity reactions to abacavir, an inhibitor of HIV (human immunodeficiency virus) nucleoside reverse transcriptase, and slow progression or non-progression of HIV infection. This study aimed to determine the prevalence of HLA-B*5701 positivity in treatment naïve people living with HIV (PLWH) and to compare age, gender, CD4+, CD8+ T lymphocyte, and HIV-RNA values of HLA-B*5701 positive people compared to negative people. Materials and Methods: Between June 2018 and November 2022, treatment-naive PLWH living with HIV who were followed at the Mersin University Faculty of Medicine Hospital, Infectious Diseases and Clinical Microbiology Polyclinic were included in the study. HLAB*5701, age, gender, CD4+, CD8+ T lymphocyte, and HIV-RNA values at the first admission to the hospital were extracted from the patient files and hospital information system. The positivity rate of HLA-B*5701 and the age, gender, CD4+, CD8+ T lymphocyte, and HIV-RNA values at the first admission of people living with HIV who tested positive for HLA-B*5701 were statistically analyzed compared to those who tested negative. Results: Of 375 patients, 49 (13.0%) were female and 326 (87.0%) were male. Five (1.3%) of 375 patients were found to be HLAB*5701 positive. One of the five patients was female, and four were male, with a mean age of 50.6 ± 24.6 years. The mean HIV-RNA value of HLA-B*5701-positive individuals was 251.596 ± 479.232 copies/mL, CD4+ T lymphocyte count was 539.4 ± 328.7/μL, and CD8+ T lymphocyte count was 793.2 ± 392.6/μL. The mean CD4+ T lymphocyte count was 446.4 ± 265.3/μL, CD8+ T lymphocyte count was 1261.1 ± 832.4/μL and HIV-RNA value was 815.668 ± 3.223.024 copies/mL in 370 patients whose HLA-B*5701 tests were negative. Conclusion: In the study, HLA-B*5701 positivity was identified in 1.3% of people living with HIV. Despite the low rate, it is suggested that HLA-B*5701 screening be conducted to prevent hypersensitivity reactions with high mortality. However, further studies are needed for cost-effectiveness analysis in regions with low prevalence.
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