Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells
Farahnaz Barahuie,
Dena Dorniani,
Bullo Saifullah,
Palanisamy Arulselvan,
Mohd Zobir Hussein,
Ravindran Jaganathan,
Fawzi Mohamed Amin El-Fagaih,
Ariyati Retno Pratiwi
Affiliations
Farahnaz Barahuie
Faculty of Industry & Mining (Khash), University of Sistan and Baluchestan, Zahedan, Iran
Dena Dorniani
Chemistry Department, University of Sheffield, Dainton Building, Brook Hill, Sheffield, S3 7HF, UK
Bullo Saifullah
Department of Human and Rehabilitation Sciences, The Begum Nusrat Bhutto Women University, Sukkur, Sindh, Pakistan
Palanisamy Arulselvan
Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 602 105, India
Mohd Zobir Hussein
Faculty of Dentistry, Brawijaya University, Malang, Indonesia; Corresponging author.
Ravindran Jaganathan
Microbiology Unit, Preclinical Department, Faculty of Medicine, University Kuala Lumpur, Royal College of Medicine Perak (UniKL-RCMP), Ipoh-30450, Perak, Malaysia
Fawzi Mohamed Amin El-Fagaih
Department of Chemical and Petrochemical Engineering, The College of Engineering & Architecture, Initial Campus, Birkat Al Mouz Nizwa, Oman
Ariyati Retno Pratiwi
Faculty of Dentistry, Brawijaya University, Malang, Indonesia
The engineered nano-vehicle was constructed using magnetic iron oxide nanoparticles (MIONs) and chitosan (CTS) to stabilize anticancer agent vanillic acid (VNA) which was loaded on CTS-coated MIONs nanocarrier, and more importantly, to achieve sustained VNA release and subsequent proper anticancer activity. The new thermally stable VNA-CTS- MIONs nanocomposite was spherical with a middle diameter of 6 nm and had a high drug loading of about 11.8 %. The MIONs and resulting nanocomposite were composed of pure magnetite and therefore, were superparamagnetic with saturation magnetizations of 53.3 and 45.7 emu.g−1, respectively. The release profiles of VNA from VNA-CTS-MIONs nanocomposite in different pH values were sustained and showed controlled pH-responsive delivery of the loaded VNA with 89 % and 74 % percentage release within 2354 and 4046 min at pH 5 and 7.4, respectively, as well as were in accordance with the pseudo-second-order model. The VNA-CTS-MIONs nanocomposite treatment at diverse concentrations remarkably decreased the viability and promoted ROS accumulation and apoptosis in the MDA-MB-231 breast cancer cells. Hence, it can be a propitious candidate for the management of breast cancer in the future.
