A cost-effectiveness analysis of mupirocin and chlorhexidine gluconate for Staphylococcus aureus decolonization prior to hip and knee arthroplasty in Alberta, Canada compared to standard of care

Antimicrobial Resistance and Infection Control. 2019;8(1):1-8 DOI 10.1186/s13756-019-0568-5


Journal Homepage

Journal Title: Antimicrobial Resistance and Infection Control

ISSN: 2047-2994 (Online)

Publisher: BMC

LCC Subject Category: Medicine: Internal medicine: Infectious and parasitic diseases

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML



Elissa Rennert-May (Departments of Medicine and Community Health Sciences, University of Calgary)

John Conly (Departments of Medicine; Microbiology, Immunology and Infectious Diseases; Pathology and Laboratory Medicine, O’Brien Institute for Public Health; Snyder Institute for Chronic Diseases, University of Calgary)

Stephanie Smith (Department of Medicine, University of Alberta)

Shannon Puloski (Department of Surgery, University of Calgary)

Elizabeth Henderson (Department of Community Health Sciences, University of Calgary)

Flora Au (Department of Medicine, University of Calgary)

Braden Manns (Departments of Medicine and Community Health Sciences, O’Brien Institute for Public Health and Libin Cardiovascular Institute, University of Calgary)


Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 13 weeks


Abstract | Full Text

Abstract Background While decolonization of Staphylococcus aureus reduces surgical site infection (SSI) rates following hip and knee arthroplasty, its cost-effectiveness is uncertain. We sought to examine the cost-effectiveness of a decolonization protocol for Staphylococcus aureus prior to hip and knee replacement in Alberta compared to standard care – no decolonization. Methods Decision analytic models and a probabilistic sensitivity analysis were used for a cost-effectiveness analysis, with the effectiveness of decolonization based on a large published pre- and post- intervention trial. The primary outcomes of the models were infections prevented and health care costs. We modelled the cost-effectiveness of decolonization in a hypothetical cohort of adult patients undergoing hip and knee replacement in Alberta, Canada. Information on the incidence of complex surgical site infections (SSIs), as well as the cost of care for patients with and without SSIs was taken from a provincial infection control database, and health administrative data. Results Use of the decolonization bundle was cost saving compared to usual care ($153/person), and resulted in 16 complex Staphylococcus aureus SSIs annually as opposed to 32 (with approximately 8000 hip or knee arthroplasties performed). The probabilistic sensitivity analysis demonstrated that the majority (84%) of the time the decolonization bundle was cost saving. The model was robust to one-way sensitivity analyses conducted within plausible ranges. There were small upfront costs associated with using a decolonization protocol, however, this model demonstrated cost savings over one year. In a Markov model that considered the impact of a decolonization bundle over a lifetime as it pertained to the need for subsequent joint replacements and patient quality of life, the bundle still resulted in cost savings ($161/person). Conclusions Decolonization for Staphylococcus aureus prior to hip and knee replacements resulted in cost savings and fewer SSIs, and should be considered prior to these procedures.