Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

Elizabeth A. LaMarca; Elizabeth A. LaMarca; Elizabeth A. LaMarca; Elizabeth A. LaMarca; Samuel K. Powell; Samuel K. Powell; Samuel K. Powell; Samuel K. Powell; Schahram Akbarian; Schahram Akbarian; Schahram Akbarian; Kristen J. Brennand; Kristen J. Brennand; Kristen J. Brennand; Kristen J. Brennand

doi:10.3389/fped.2018.00082

Frontiers in Pediatrics (Apr 2018)

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

Elizabeth A. LaMarca,
Elizabeth A. LaMarca,
Elizabeth A. LaMarca,
Elizabeth A. LaMarca,
Samuel K. Powell,
Samuel K. Powell,
Samuel K. Powell,
Samuel K. Powell,
Schahram Akbarian,
Schahram Akbarian,
Schahram Akbarian,
Kristen J. Brennand,
Kristen J. Brennand,
Kristen J. Brennand,
Kristen J. Brennand

Affiliations

Elizabeth A. LaMarca: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Elizabeth A. LaMarca: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Elizabeth A. LaMarca: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Elizabeth A. LaMarca: Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Samuel K. Powell: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Samuel K. Powell: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Samuel K. Powell: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Samuel K. Powell: Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Schahram Akbarian: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Schahram Akbarian: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Schahram Akbarian: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Kristen J. Brennand: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Kristen J. Brennand: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Kristen J. Brennand: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States
Kristen J. Brennand: Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, United States

DOI: https://doi.org/10.3389/fped.2018.00082
Journal volume & issue: Vol. 6

Abstract

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Human-induced pluripotent stem cells (hiPSCs) have revolutionized our ability to model neuropsychiatric and neurodegenerative diseases, and recent progress in the field is paving the way for improved therapeutics. In this review, we discuss major advances in generating hiPSC-derived neural cells and cutting-edge techniques that are transforming hiPSC technology, such as three-dimensional “mini-brains” and clustered, regularly interspersed short palindromic repeats (CRISPR)-Cas systems. We examine specific examples of how hiPSC-derived neural cells are being used to uncover the pathophysiology of schizophrenia and Parkinson’s disease, and consider the future of this groundbreaking research.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

About the journal

Abstract

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