Progress of research on role of lipotoxicity in pathogenesis of sarcopenia

Abstract

Sarcopenia is a serious health concern that must be payed attention by aged people. The occurrence of sarcopenia in obese older individuals may be intricately linked to lipotoxic substances such as free fatty acids (FFA), diacylglycerols (DAG), and ceramides, which are toxic to skeletal muscle cells. Lipotoxic substances induce inflammatory responses, oxidative stress, endoplasmic reticulum stress, and insulin resistance in skeletal muscle cells, disrupting protein metabolism and impairing regeneration and then lead to the onset of sarcopenia. Up to the present, the precise mechanisms by which lipotoxicity in skeletal muscle results in the development of sarcopenia remain incompletely understood. Further research may highlight the orientation for the prevention and treatment of sarcopenia.

Keywords

• free fatty acids|lipotoxicity|sarcopenia|pathogenesis