Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations

Yili Xu; Mei Huang; Wenzhen He; Chen He; Kaixuan Chen; Jing Hou; Min Huang; Yurui Jiao; Ran Liu; Nanyu Zou; Ling Liu; Changjun Li; Changjun Li; Changjun Li

doi:10.3389/fcell.2022.770931

Frontiers in Cell and Developmental Biology (Jan 2022)

Heterotopic Ossification: Clinical Features, Basic Researches, and Mechanical Stimulations

Yili Xu,
Mei Huang,
Wenzhen He,
Chen He,
Kaixuan Chen,
Jing Hou,
Min Huang,
Yurui Jiao,
Ran Liu,
Nanyu Zou,
Ling Liu,
Changjun Li,
Changjun Li,
Changjun Li

Affiliations

Yili Xu: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Mei Huang: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Wenzhen He: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Chen He: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Kaixuan Chen: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Jing Hou: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Min Huang: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Yurui Jiao: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Ran Liu: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Nanyu Zou: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Ling Liu: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Changjun Li: Department of Endocrinology, Endocrinology Research Center, The Xiangya Hospital of Central South University, Changsha, China
Changjun Li: National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China
Changjun Li: Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China

DOI: https://doi.org/10.3389/fcell.2022.770931
Journal volume & issue: Vol. 10

Abstract

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Heterotopic ossification (HO) is defined as the occurrence of extraskeletal bone in soft tissue. Although this pathological osteogenesis process involves the participation of osteoblasts and osteoclasts during the formation of bone structures, it differs from normal physiological osteogenesis in many features. In this article, the primary characteristics of heterotopic ossification are reviewed from both clinical and basic research perspectives, with a special highlight on the influence of mechanics on heterotopic ossification, which serves an important role in the prophylaxis and treatment of HO.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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