Nature Communications (Jan 2016)

A role for Separase in telomere protection

  • Francesca Cipressa,
  • Patrizia Morciano,
  • Giuseppe Bosso,
  • Linda Mannini,
  • Alessandra Galati,
  • Grazia Daniela Raffa,
  • Stefano Cacchione,
  • Antonio Musio,
  • Giovanni Cenci

DOI
https://doi.org/10.1038/ncomms10405
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity. Here, the authors show that Separase is enriched at Drosophila telomeres and loss of Sse, the gene encoding Separase, leads to telomere defects, suggesting a role for Separase in telomere protection.