Nature Communications (Jan 2020)
Comprehensive T cell repertoire characterization of non-small cell lung cancer
- Alexandre Reuben,
- Jiexin Zhang,
- Shin-Heng Chiou,
- Rachel M. Gittelman,
- Jun Li,
- Won-Chul Lee,
- Junya Fujimoto,
- Carmen Behrens,
- Xiaoke Liu,
- Feng Wang,
- Kelly Quek,
- Chunlin Wang,
- Farrah Kheradmand,
- Runzhe Chen,
- Chi-Wan Chow,
- Heather Lin,
- Chantale Bernatchez,
- Ali Jalali,
- Xin Hu,
- Chang-Jiun Wu,
- Agda Karina Eterovic,
- Edwin Roger Parra,
- Erik Yusko,
- Ryan Emerson,
- Sharon Benzeno,
- Marissa Vignali,
- Xifeng Wu,
- Yuanqing Ye,
- Latasha D. Little,
- Curtis Gumbs,
- Xizeng Mao,
- Xingzhi Song,
- Samantha Tippen,
- Rebecca L. Thornton,
- Tina Cascone,
- Alexandra Snyder,
- Jennifer A. Wargo,
- Roy Herbst,
- Stephen Swisher,
- Humam Kadara,
- Cesar Moran,
- Neda Kalhor,
- Jianhua Zhang,
- Paul Scheet,
- Ara A. Vaporciyan,
- Boris Sepesi,
- Don L. Gibbons,
- Harlan Robins,
- Patrick Hwu,
- John V. Heymach,
- Padmanee Sharma,
- James P. Allison,
- Veera Baladandayuthapani,
- Jack J. Lee,
- Mark M. Davis,
- Ignacio I. Wistuba,
- P. Andrew Futreal,
- Jianjun Zhang
Affiliations
- Alexandre Reuben
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Jiexin Zhang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Shin-Heng Chiou
- Institute for Immunity, Transplantation, and Infection Operations, Howard Hughes Medical Institute
- Rachel M. Gittelman
- Adaptive Biotechnologies
- Jun Li
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Won-Chul Lee
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Junya Fujimoto
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Carmen Behrens
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xiaoke Liu
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Feng Wang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Kelly Quek
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chunlin Wang
- iRepertoire, Inc.
- Farrah Kheradmand
- Baylor College of Medicine
- Runzhe Chen
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Chi-Wan Chow
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Heather Lin
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Chantale Bernatchez
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Ali Jalali
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center
- Xin Hu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Chang-Jiun Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Agda Karina Eterovic
- Department of Systems Biology, The University of Texas MD Anderson Cancer Center
- Edwin Roger Parra
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Erik Yusko
- Adaptive Biotechnologies
- Ryan Emerson
- Adaptive Biotechnologies
- Sharon Benzeno
- Adaptive Biotechnologies
- Marissa Vignali
- Adaptive Biotechnologies
- Xifeng Wu
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Yuanqing Ye
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Latasha D. Little
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Xizeng Mao
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- Xingzhi Song
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Samantha Tippen
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Rebecca L. Thornton
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Tina Cascone
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Alexandra Snyder
- Adaptive Biotechnologies
- Jennifer A. Wargo
- Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center
- Roy Herbst
- Department of Medical Oncology, 333 Cedar Street, Yale Cancer Center
- Stephen Swisher
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Humam Kadara
- Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center
- Cesar Moran
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Neda Kalhor
- Department of Pathology, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Paul Scheet
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Ara A. Vaporciyan
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Boris Sepesi
- Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Harlan Robins
- Adaptive Biotechnologies
- Patrick Hwu
- Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- Padmanee Sharma
- Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center
- James P. Allison
- Department of Immunology, The University of Texas MD Anderson Cancer Center
- Veera Baladandayuthapani
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Jack J. Lee
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Mark M. Davis
- Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford
- Ignacio I. Wistuba
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Jianjun Zhang
- Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-14273-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.
