Identification of interferon-stimulated genes that attenuate Ebola virus infection

Makoto Kuroda; Peter J. Halfmann; Lindsay Hill-Batorski; Makoto Ozawa; Tiago J. S. Lopes; Gabriele Neumann; John W. Schoggins; Charles M. Rice; Yoshihiro Kawaoka

doi:10.1038/s41467-020-16768-7

Nature Communications (Jun 2020)

Identification of interferon-stimulated genes that attenuate Ebola virus infection

Makoto Kuroda,
Peter J. Halfmann,
Lindsay Hill-Batorski,
Makoto Ozawa,
Tiago J. S. Lopes,
Gabriele Neumann,
John W. Schoggins,
Charles M. Rice,
Yoshihiro Kawaoka

Affiliations

Makoto Kuroda: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison
Peter J. Halfmann: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison
Lindsay Hill-Batorski: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison
Makoto Ozawa: Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University
Tiago J. S. Lopes: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison
Gabriele Neumann: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison
John W. Schoggins: Department of Microbiology, UT Southwestern Medical Center
Charles M. Rice: Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University
Yoshihiro Kawaoka: Department of Pathobiological Sciences, School of Veterinary Medicine, Influenza Research Institute, University of Wisconsin–Madison

DOI: https://doi.org/10.1038/s41467-020-16768-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Here, Kuroda et al. screen a library of nearly 400 interferon-stimulated genes (ISGs) and identify several ISGs that inhibit Ebola virus entry, viral transcription/replication, or virion formation. The study provides insights into interactions between Ebola and the host cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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