Syntheses of Hydrazino-and Azo-Sphingosine Derivatives and Their Evaluation as SphK Inhibitors

Abstract

Bioactive sphingolipids have been recognized to play important roles in both normal and pathological physiology related to the regulations of cell proliferation, differentiation, survival, trafficking, and cell death. [...]

Keywords

• sphingolipids
• sphingosine kinase inhibitors
• aziridination
• N-amino aziridines
• ring-opening of N-phthalimido aziridines