Medicina (Sep 2024)

Novel Models for Assessing and Pathophysiology of Hepatic Ischemia–Reperfusion Injury Mechanisms

  • Connor Whalen,
  • Arun Verma,
  • Kento Kurashima,
  • Jasmine Carter,
  • Hala Nazzal,
  • Ajay Jain

DOI
https://doi.org/10.3390/medicina60091507
Journal volume & issue
Vol. 60, no. 9
p. 1507

Abstract

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Hepatic ischemia–reperfusion injury (IRI) is a major cause of postoperative hepatic dysfunction and liver failure involving cellular damage to previously ischemic tissues to which blood flow is restored. The reestablishment of blood flow is essential for salvaging ischemic tissues. The reperfusion itself, however, can paradoxically lead to further cellular damage, which involves a multi-factorial process resulting in extensive tissue damage, which can threaten the function and viability of the liver and other organ systems. The following review outlines multiple models for in-lab analysis of the various hepatic IRI mechanisms, including murine, porcine, cell lines, and machine perfusion models.

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