Nature Communications (Jul 2022)

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells

  • Yingying Ye,
  • Mohammad Barghouth,
  • Haiqiang Dou,
  • Cheng Luan,
  • Yongzhi Wang,
  • Alexandros Karagiannopoulos,
  • Xiaoping Jiang,
  • Ulrika Krus,
  • Malin Fex,
  • Quan Zhang,
  • Lena Eliasson,
  • Patrik Rorsman,
  • Enming Zhang,
  • Erik Renström

DOI
https://doi.org/10.1038/s41467-022-31103-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Insulin secretion depends on action potential firing in pancreatic islet beta-cells, but the underlying mechanism is unclear. Here, the authors show that activation of the mechanosensor ion channel PIEZO1 plays a central role in beta-cell electrical activity and insulin release.