Molecules (Apr 2012)

Antiangiogenic Polyketides from Peperomia dindygulensis Miq.

  • Hong-Zhuan Chen,
  • Guo-Hong Yang,
  • Chao Fang,
  • Yi-Fang Yang,
  • Xue-Mei Qin,
  • Chao Wang,
  • Qin Lu,
  • Gui-Xiu Li,
  • Wen-Jun Zhu,
  • Mei Zhao,
  • De-Hong Yu,
  • Meng-Gan Lin,
  • Qi-Wei Wang

DOI
https://doi.org/10.3390/molecules17044474
Journal volume & issue
Vol. 17, no. 4
pp. 4474 – 4483

Abstract

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Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.

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