Advances in research on the pathogenesis of depression based on signaling pathways

Abstract

Depression is an affective disorder that endangers human health, and its main clinical feature is significant and persistent depression. The pathological mechanism of depression is complex and has not been fully elucidated so far. In recent years, with the further study of molecular biology techniques, depression is closely related with mood regulation, cognitive function, function changes of specific protein and abnormal cell signal transduction pathways in the brain, causing cell dysfunction, which affects the brain nerve cells apoptosis regeneration mechanism of trigger depressive symptoms. By referring to and sorting out relevant literatures, this paper comprehensively described the research progress of the signal transduction mechanism of cyclic adenosine phosphate (cAMP), mitogen-activated protein kinase (MAPK) and calmodulin kinase (CaMK) in depression, so as to provide reference for explaining the pathogenesis of depression and developing treatment plans.