Mucosal immunity to the pathogens and tumors involving system "lectins of probiotics - glycopolymers"

Abstract

The overview of own works is devoted to the new insights to mucosal innate immunity functioning. We described multifunctional lectin systems of probiotic bacteria (LSPB) and their complexes which recognize a wide spectrum of selected glycoconjugates. LSPB (separately or in combinations with other antimicrobials and antipathogen factors) are important contributors to biotope distant protection against pathogens. Being metabolomebiotics, LSPB form reversible complexes to natural and artificial glycopolymers of mucin type that allows building on duty dynamic network of directed cascades of replies of mucosal innate immunity. Probiotic molecular-cellular network "LSPB - glycopolymers" serves as an important synergistic system participating in biotope microbiocenosis antipathogen resistance and in Cross-Talking communications with human protective cells and systems to support prolonged healthy status of mucosa. This network influences mucosa pores, affine texture, tropism and redistribution in biotope. Mucosal innate immunity strategies of LSPB and their complexes against microbial and viral pathogens, early tumor-like mucosal cells are proposed. Biological properties of artificial glycopolymers interacted in LS were compared.

Keywords

• mucosa
• congenital immunity
• probiotic lectins
• lectin system
• artificial glycolymers
• mucins
• microbiocenosis
• biotope
• pathogens
• tumor-like cells