The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L. Vijayaraj; Rebecca Feltham; Maryam Rashidi; Daniel Frank; Zhengyang Liu; Daniel S. Simpson; Gregor Ebert; Angelina Vince; Marco J. Herold; Andrew Kueh; Jaclyn S. Pearson; Laura F. Dagley; James M. Murphy; Andrew I. Webb; Kate E. Lawlor; James E. Vince

doi:10.1038/s41467-021-22979-3

Nature Communications (May 2021)

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation

Swarna L. Vijayaraj,
Rebecca Feltham,
Maryam Rashidi,
Daniel Frank,
Zhengyang Liu,
Daniel S. Simpson,
Gregor Ebert,
Angelina Vince,
Marco J. Herold,
Andrew Kueh,
Jaclyn S. Pearson,
Laura F. Dagley,
James M. Murphy,
Andrew I. Webb,
Kate E. Lawlor,
James E. Vince

Affiliations

Swarna L. Vijayaraj: The Walter and Eliza Hall Institute of Medical Research
Rebecca Feltham: The Walter and Eliza Hall Institute of Medical Research
Maryam Rashidi: The Walter and Eliza Hall Institute of Medical Research
Daniel Frank: The Walter and Eliza Hall Institute of Medical Research
Zhengyang Liu: The Walter and Eliza Hall Institute of Medical Research
Daniel S. Simpson: The Walter and Eliza Hall Institute of Medical Research
Gregor Ebert: The Walter and Eliza Hall Institute of Medical Research
Angelina Vince: The Walter and Eliza Hall Institute of Medical Research
Marco J. Herold: The Walter and Eliza Hall Institute of Medical Research
Andrew Kueh: The Walter and Eliza Hall Institute of Medical Research
Jaclyn S. Pearson: Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Laura F. Dagley: The Walter and Eliza Hall Institute of Medical Research
James M. Murphy: The Walter and Eliza Hall Institute of Medical Research
Andrew I. Webb: The Walter and Eliza Hall Institute of Medical Research
Kate E. Lawlor: The Walter and Eliza Hall Institute of Medical Research
James E. Vince: The Walter and Eliza Hall Institute of Medical Research

DOI: https://doi.org/10.1038/s41467-021-22979-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

Hyperactivation of inflammasome-induced IL-1β can cause immunopathology and is a feature of autoinflammatory diseases. Here, the authors show how ubiquitination of IL-1β limits its activity by targeting it for proteasomal degradation and preventing its cleavage by caspase-1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal