Formulation and in vitro evaluation of inosine acedoben dimepranol tablets

Abstract

The present work was carried out to formulate and evaluate immediate release tablets of Inosine Acedoben Dimepranol (IAD). Tablets were prepared by wet granulation process to overcome the poor compression properties of IAD powder and produce high-dose tablets. Various type of binders and disintegrants like Povidone K-30, K-25, wheat starch, mannitol were used to prepare some series of tablets. Granules were evaluated for pre-compression parameters and tablets were evaluated for post- compression parameters. The composition batch № IAD L03 was the best for producing IAD 500 mg tablets. The optimal lubricant is glycerol dibehenate at a concentration of 3.08%. Optimized formulation was evaluated for in-vitro dissolution test. Stability studies were performed for the selected composition.