Вісник проблем біології і медицини (Dec 2020)

EFFECT OF COURSE APPLICATION OF QUERCETIN ON RESISTANCE TO HYPOXIA IN ELDERLY PEOPLE WITH METABOLIC SYNDROME

  • Korkushko O. V.,
  • Shatilo V. B.,
  • Antoniuk-Shcheglova - I. A.,
  • Bondarenko O. V.,
  • Naskalova S. S.,
  • Gavalko A. V.,
  • Grib O. M.

DOI
https://doi.org/10.29254/2077-4214-2020-4-158-156-160
Journal volume & issue
no. 4
pp. 156 – 160

Abstract

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The search for safe and effective drugs that can influence the course and correction of metabolic syndrome, especially in the older age group, has drawn attention to the possibilities of using an antioxidant from the bioflavonoid group, quercetin. The search for literature data indicates the absence of clinical studies on the use of quercetin in order to increase resistance to hypoxia in elderly people with metabolic syndrome. The aim of the study. To establish the response to an acute hypoxic test in the elderly people with metabolic syndrome after a course of quercetin in comparison with the control group. The object was 110 elderly patients with metabolic syndrome criteria, of which 55 people took quercetin (drug “Kvertin” PAO SPC «Borshchahivskiy CPP», 80 mg three times a day for 3 months), and 55 people took placebo and formed a control group. Methods. Anthropometric measurements; biochemical study with determination of glucose in blood plasma, lipids in blood serum; measurement of blood pressure; hypoxic test to determine resistance to hypoxia. Results. The course use of quercetin led to a less significant decrease in SрO2 in the main group of patients during the hypoxic test. Also, in the main group, after treatment, there was a statistically significant decrease in systolic and diastolic blood pressure, both at the beginning of HP and at 20 minutes of HP compared to the baseline level and the control group. In addition, there was a statistically significant decrease in the double product – an indicator that indirectly characterizes the level of oxygen consumption by the myocardium in the main group compared to the control group. Conclusions. Course use of quercetin significantly increases the body’s resistance to hypoxia in elderly patients with metabolic syndrome. The antihypoxic effect of quercetin can be used to correct conditions associated with oxygen deficiency.

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