Mapping the landscape of genetic dependencies in chordoma

Tanaz Sharifnia; Mathias J. Wawer; Amy Goodale; Yenarae Lee; Mariya Kazachkova; Joshua M. Dempster; Sandrine Muller; Joan Levy; Daniel M. Freed; Josh Sommer; Jérémie Kalfon; Francisca Vazquez; William C. Hahn; David E. Root; Paul A. Clemons; Stuart L. Schreiber

doi:10.1038/s41467-023-37593-8

Nature Communications (Apr 2023)

Mapping the landscape of genetic dependencies in chordoma

Tanaz Sharifnia,
Mathias J. Wawer,
Amy Goodale,
Yenarae Lee,
Mariya Kazachkova,
Joshua M. Dempster,
Sandrine Muller,
Joan Levy,
Daniel M. Freed,
Josh Sommer,
Jérémie Kalfon,
Francisca Vazquez,
William C. Hahn,
David E. Root,
Paul A. Clemons,
Stuart L. Schreiber

Affiliations

Tanaz Sharifnia: Broad Institute of Harvard and MIT
Mathias J. Wawer: Broad Institute of Harvard and MIT
Amy Goodale: Broad Institute of Harvard and MIT
Yenarae Lee: Broad Institute of Harvard and MIT
Mariya Kazachkova: Broad Institute of Harvard and MIT
Joshua M. Dempster: Broad Institute of Harvard and MIT
Sandrine Muller: Broad Institute of Harvard and MIT
Joan Levy: Chordoma Foundation
Daniel M. Freed: Chordoma Foundation
Josh Sommer: Chordoma Foundation
Jérémie Kalfon: Broad Institute of Harvard and MIT
Francisca Vazquez: Broad Institute of Harvard and MIT
William C. Hahn: Broad Institute of Harvard and MIT
David E. Root: Broad Institute of Harvard and MIT
Paul A. Clemons: Broad Institute of Harvard and MIT
Stuart L. Schreiber: Broad Institute of Harvard and MIT

DOI: https://doi.org/10.1038/s41467-023-37593-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

Read online

Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively essential genes and therapeutic targets in chordoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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