Human mpox co-infection with advanced HIV-1 and XDR-TB in a MSM patient previously vaccinated against smallpox: A case report

Yuan Fang; Fuchun Wang; Taiyi Jiang; Junyi Duan; Tao Huang; Hao Liu; Lin Jia; Han Jia; Benyong Yan; Mei Zhang; Wen Wang; Caiping Guo; Lifeng Liu; Yuening Zhang; Tong Zhang

Biosafety and Health (Jun 2024)

Human mpox co-infection with advanced HIV-1 and XDR-TB in a MSM patient previously vaccinated against smallpox: A case report

Yuan Fang,
Fuchun Wang,
Taiyi Jiang,
Junyi Duan,
Tao Huang,
Hao Liu,
Lin Jia,
Han Jia,
Benyong Yan,
Mei Zhang,
Wen Wang,
Caiping Guo,
Lifeng Liu,
Yuening Zhang,
Tong Zhang

Affiliations

Yuan Fang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Fuchun Wang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Taiyi Jiang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Junyi Duan: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Tao Huang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Hao Liu: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Lin Jia: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Han Jia: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Benyong Yan: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Mei Zhang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Wen Wang: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Caiping Guo: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Lifeng Liu: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Yuening Zhang: Corresponding authors: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China (Y. Zhang and T. Zhang).; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China
Tong Zhang: Corresponding authors: Beijing Youan Hospital, Capital Medical University, Beijing 100069, China (Y. Zhang and T. Zhang).; Beijing Youan Hospital, Capital Medical University, Beijing 100069, China

Journal volume & issue: Vol. 6, no. 3
pp. 186 – 190

Abstract

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Mpox is a zoonotic infectious disease caused by the mpox virus (MPXV). Historically, the majority of mpox cases have been documented in Central Africa. However, since May 2022, there has been a notable rise in reported cases from regions beyond Africa. Currently, over 110 countries spanning Europe, North America, South America, Asia, and other territories have reported mpox infections. This report details a case involving a patient who identifies as a man who has sex with men (MSM) and is concurrently infected with MPXV, human immunodeficiency virus type 1 (HIV-1), Pneumocystis jiroveci, as well as extensively drug-resistant tuberculosis (XDR-TB). This patient had also received a vaccination for smallpox in the past. Additionally, we provide photographic documentation charting the progression of dermatological manifestations associated with mpox. This case highlights the significance of sexual intercourse as a crucial mode of transmission for mpox. The rapid and widespread dissemination of the MPXV across various regions, especially among MSM communities, underscores the importance of enhancing preventive education efforts targeted at high-risk populations.

Published in Biosafety and Health

ISSN: 2590-0536 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/biosafety-and-health/

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