Dyslipidemia and its relationship with chronic non-communicable diseases (according to the MERIDIAN-RO study)

Abstract

MERIDIAN-RO, a prospective cohort cross-sectional study with retrospective component, aimed to evaluate the incidence of lipid metabolism disorders in the Ryazan region and their relationship with chronic non-communicable diseases. In 2011, 1,622 people (1,220 urban and 402 rural) aged 25--64 years (mean age - 43,4 ± 11,4 years) 42.6% of which were males and 53.8% females, were included in the study. The cohort was observed for 36 months, the end points were evaluated annually. Biochemical samples, ECG and results of a survey using standardized questionnaire were assessed. A total cholesterol level above 2.5 mmol/L and/or low-density lipoprotein level above 2.5 mmol/L were considered as dyslipidemia. According to the study, the incidence of dyslipidemia in the Ryazan region was high and amounted to 84.1%. A less favourable lipid profile was registered in rural residents, requiring a more enhanced preventive intervention. Dyslipidemia in combination with CNCD increased the risk of adverse events. Of all lipid markers, only apoB was associated with the development of socially significant CNCD (CAD/MI/stroke, DM and CKD), thus making it necessary to include it in the standard examination of people with elevated total cholesterol and/or LDL.

Keywords

• дислипидемии
• хронические неинфекционные заболевания
• аполипопротеин
• холестерин
• профилактика
• dyslipidemia
• cncd
• apolipoprotein
• cholesterol
• prevention
• rosulip