Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

Abstract

Highlights • Prostate cancer is among the leading causes of death in men where targeting autophagy is of importance in treatment; • Autophagy governs proliferation and metastasis capacity of prostate cancer cells; • Autophagy modulation is of interest in improving the therapeutic response of prostate cancer cells; • Molecular pathways, especially involving non-coding RNAs, regulate autophagy in prostate cancer; • Autophagy possesses both diagnostic and prognostic roles in prostate cancer, with promises for clinical application.

Keywords

• Anti-tumor compounds
• Autophagy
• Biomarker
• Non-coding RNAs
• Prostate cancer
• Therapy response