Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review

Pavlo Petakh; Pavlo Petakh; Khrystyna Duve; Valentyn Oksenych; Payam Behzadi; Oleksandr Kamyshnyi

doi:10.3389/fnins.2024.1394953

Frontiers in Neuroscience (Jun 2024)

Molecular mechanisms and therapeutic possibilities of short-chain fatty acids in posttraumatic stress disorder patients: a mini-review

Pavlo Petakh,
Pavlo Petakh,
Khrystyna Duve,
Valentyn Oksenych,
Payam Behzadi,
Oleksandr Kamyshnyi

Affiliations

Pavlo Petakh: Department of Biochemistry and Pharmacology, Uzhhorod National University, Uzhhorod, Ukraine
Pavlo Petakh: Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Khrystyna Duve: Department of Neurology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Valentyn Oksenych: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway
Payam Behzadi: Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran
Oleksandr Kamyshnyi: Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DOI: https://doi.org/10.3389/fnins.2024.1394953
Journal volume & issue: Vol. 18

Abstract

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This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting the microbiota-gut-brain axis, this study investigated the bidirectional communication between the gut microbiome and mental health. SCFAs, byproducts of gut microbial fermentation, have been examined for their potential impact on PTSD, with a focus on molecular mechanisms and therapeutic interventions. This review discusses changes in SCFA levels and bacterial profiles in individuals with PTSD, emphasizing the need for further research. Promising outcomes from clinical trials using probiotics and fermented formulations suggest potential avenues for PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, and employing advanced computational methods, with the goal of deepening our understanding of the role of SCFAs in PTSD and exploring microbiota-targeted interventions.

Published in Frontiers in Neuroscience

ISSN: 1662-4548 (Print); 1662-453X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/neuroscience

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