Nature Communications (Sep 2021)

Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera

  • Jesse R. Poganik,
  • Kuan-Ting Huang,
  • Saba Parvez,
  • Yi Zhao,
  • Sruthi Raja,
  • Marcus J. C. Long,
  • Yimon Aye

DOI
https://doi.org/10.1038/s41467-021-25466-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The mechanism-of-action of many electrohilic drugs remains poorly understood. Here, the authors use a redox-targeting approach to elucidate the basis for the innate immune cell toxicity of dimethyl fumarate, showing that it modifies Keap1 to trigger mitochondrial-targeted neutrophil/macrophage apoptosis.