A study of recipient related predictors of success in oocyte donation program

Abstract

Background: Oocyte donation is an invaluable therapy for couples with impending or complete ovarian failure. In addition, oocyte donation affords a scientific opportunity to study the unique biologic participation of the uterus in the process of human embryo implantation. Aim: To identify the recipient variables that may have a significant impact on pregnancy outcome in order to optimize results of an oocyte donation program. Design and Settings: A prospective study conducted from March 1, 2010 to March 31, 2011 at a private tertiary care IVF Clinic. Materials and methods A total of 270 recipients resulting in embryo transfer as a result of oocyte donation were enrolled. Clinical and Ongoing pregnancy rates, Implantation rates were calculated according to different age groups, Endometrial thickness, Indication, Day and number of embryos transferred. Data was evaluated as chi square analyses with comparative significance determined at P 8 mm is considered ideal before transfer. Transfer of two selected embryos on day 3 yields a favorable pregnancy outcome with reduced multiple pregnancy rates. Recipient′s age above 45 years has negative impact on pregnancy outcome whereas embryo transfers on Day 3 yields better pregnancy

Keywords

• Aging uterus
• embryo implantation
• endometrial thickness
• oocyte donation
• uterine receptivity
• uterine senescence