CD27/CD70 and idiopathic pulmonary fibrosis

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease marked by the significant involvement of fibroblasts, macrophages and lymphocytes. The CD27/CD70 axis is pivotal in shaping the immune microenvironment present in the fibrotic aeras of lungs. This mentioned interaction involves molecular pathways that work in tandem with lung immune cells, particularly exerting a suppressive influence in the early phases of pulmonary fibrosis. Consequently, the CD27/CD70 axis presents a promising new target for immunotherapy in IPF.

Keywords

• idiopathic pulmonary fibrosis|cd27/cd70 axis|pi3k/akt pathway