Revista da Escola de Enfermagem da USP (Oct 2014)

Antioxidant protection of statins in acute kidney injury induced by sepsis

  • Franciele do Nascimento Santos,
  • Mirian Watanabe,
  • Carolina Ferreira Vasco,
  • Cassiane Dezoti da Fonseca,
  • Maria de Fatima Fernandes Vattimo

DOI
https://doi.org/10.1590/S0080-6234201400005000007
Journal volume & issue
Vol. 48, no. 5
pp. 820 – 826

Abstract

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Objective Evaluating the effect of preconditioning with simvastatin in acute kidney injury induced by sepsis. Method Male adult Wistar rats were divided into the following groups: SHAM (control); SHAM+Statin (0.5 mg/kg simvastatin, orally); Sepsis (cecal puncture ligation – CPL); Sepsis+Statin. Physiological parameters, peritoneal fluid culture, renal function, oxidative metabolites, severity of acute kidney injury and animal survival were evaluated. Results The treatment with simvastatin in induced sepsis showed elevation of creatinine clearance with attenuation of generation of oxidative metabolites, lower severity of acute kidney injury and reduced mortality. Conclusion This investigation confirmed the renoprotection with antioxidant principle of the simvastatin in acute kidney injury induced by sepsis in an experimental model.

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