Nature Communications (Apr 2017)
Clonal evolution in myelodysplastic syndromes
- Pedro da Silva-Coelho,
- Leonie I. Kroeze,
- Kenichi Yoshida,
- Theresia N. Koorenhof-Scheele,
- Ruth Knops,
- Louis T. van de Locht,
- Aniek O. de Graaf,
- Marion Massop,
- Sarah Sandmann,
- Martin Dugas,
- Marian J. Stevens-Kroef,
- Jaroslav Cermak,
- Yuichi Shiraishi,
- Kenichi Chiba,
- Hiroko Tanaka,
- Satoru Miyano,
- Theo de Witte,
- Nicole M. A. Blijlevens,
- Petra Muus,
- Gerwin Huls,
- Bert A. van der Reijden,
- Seishi Ogawa,
- Joop H. Jansen
Affiliations
- Pedro da Silva-Coelho
- Laboratory of Hematology, Radboud University Medical Center
- Leonie I. Kroeze
- Laboratory of Hematology, Radboud University Medical Center
- Kenichi Yoshida
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto-shi
- Theresia N. Koorenhof-Scheele
- Laboratory of Hematology, Radboud University Medical Center
- Ruth Knops
- Laboratory of Hematology, Radboud University Medical Center
- Louis T. van de Locht
- Laboratory of Hematology, Radboud University Medical Center
- Aniek O. de Graaf
- Laboratory of Hematology, Radboud University Medical Center
- Marion Massop
- Laboratory of Hematology, Radboud University Medical Center
- Sarah Sandmann
- Institute of Medical Informatics, University of Münster
- Martin Dugas
- Institute of Medical Informatics, University of Münster
- Marian J. Stevens-Kroef
- Department of Human Genetics, Radboud University Medical Center
- Jaroslav Cermak
- Institute of Hematology and Blood Transfusion
- Yuichi Shiraishi
- Human Genome Center, Institute of Medical Science, The University of Tokyo
- Kenichi Chiba
- Human Genome Center, Institute of Medical Science, The University of Tokyo
- Hiroko Tanaka
- Human Genome Center, Institute of Medical Science, The University of Tokyo
- Satoru Miyano
- Human Genome Center, Institute of Medical Science, The University of Tokyo
- Theo de Witte
- Department of Tumor Immunology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Nicole M. A. Blijlevens
- Department of Hematology, Radboud University Medical Center
- Petra Muus
- Department of Hematology, Radboud University Medical Center
- Gerwin Huls
- Department of Hematology, Radboud University Medical Center
- Bert A. van der Reijden
- Laboratory of Hematology, Radboud University Medical Center
- Seishi Ogawa
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto-shi
- Joop H. Jansen
- Laboratory of Hematology, Radboud University Medical Center
- DOI
- https://doi.org/10.1038/ncomms15099
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Myelodysplastic syndromes are a broad group of haematopoietic malignancies that often progress to acute myeloid leukaemia. Here, the authors show that linear and branched evolution occurs within myelodysplastic syndrome and these patterns can be impacted by treatment.
