Cytokeratin-positive primitive neuroectodermal tumor of the prostate: Case report and review of literature

Abstract

Ewing′s sarcoma/primitive neuroectodermal tumor (ES/PNET) of the prostate is extremely rare. Here, we report a case of ES/PNET of prostate in a 24-year-old man presenting with dysuria and pelvic discomfort. Computed tomography scan revealed a heterogeneous mass involving the prostate without evidence of distant metastases. Histologically, the tumor was composed of small round blue cells strongly and diffusely positive for CD99 and epithelial markers. Fluorescence in situ hybridization confirmed rearrangement of the Ewing′s sarcoma region on chromosome 22.

Keywords

• Cytokeratin
• Ewing′s sarcoma
• poorly differentiated synovial sarcoma
• primitive neuroectodermal tumor
• prostate gland