Psoriasis: Targets and Therapy (Jun 2024)
Effectiveness and Drug Survival of Ixekizumab and Secukinumab in Patients with Moderate to Severe Plaque Psoriasis: Real-World Data from Bucharest, Romania
Abstract
Stefana Bucur,1,2 Elena-Daniela Serban,1 Bogdan Vasile Ileanu,3 Raluca Simona Costache,4,5 Alin Codrut Nicolescu,6 Traian Constantin,7,8 Daniel Octavian Costache,1,9 Maria-Magdalena Constantin1,2 1 2nd Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 2 2nd Department of Dermatology, Colentina Clinical Hospital, Bucharest, Romania; 3Center for Health Outcomes and Evaluation, Bucharest, Romania; 4Department of Internal Medicine and Gastroenterology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 5Department of Gastroenterology, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania; 6Department of Dermatology, “Agrippa Ionescu” Emergency Clinical Hospital, Bucharest, 011773, Romania; 7Department of Urology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 8Department of Urology, “Prof. Dr. Theodor Burghele” Hospital, Bucharest, 050659, Romania; 9Department of Dermatology, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, RomaniaCorrespondence: Elena-Daniela Serban, 37 Dionisie Lupu Street, Bucharest, 020021, Romania, Email [email protected]: Multiple biological therapies have been developed for the treatment of inflammatory diseases, including moderate to severe plaque psoriasis. Choosing the optimal treatment for psoriasis can depend on several factors and is strongly influenced by a drug’s efficacy and safety profile. Continuous treatment with biological therapies is recommended to achieve effective disease management in patients with psoriasis. However, in real-world, patients often discontinue biologic therapy within the first year of treatment. Therefore, in this study, we aimed to investigate the effectiveness and drug survival of two anti-interleukin 17 agents (ixekizumab and secukinumab) in a group of adult patients with moderate to severe psoriasis from Bucharest, Romania.Patients and Methods: We designed an observational, non-interventional, retrospective study of 255 adult patients with moderate to severe psoriasis receiving ixekizumab and secukinumab. We performed descriptive statistics and inferential methods, such as z-test, median test and Kaplan Meier curve comparison, to characterize the groups with two biological treatments.Results: Patients treated with ixekizumab had a longer drug survival compared to those treated with secukinumab with lower risks of non-persistence, discontinuation and switching therapy. Patients age-groups and psoriasis durations found to be significant factors in drug survival.Conclusion: This study contributes to the understanding of the drug survival profile and the factors that may influence it in ixekizumab and secukinumab treatment in a real-world setting.Keywords: anti-IL-17 effectiveness, anti-IL-17 drug survival, ixekizumab, secukinumab
