Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer

Koji Matsuo; Kazuhiro Tanabe; Masaru Hayashi; Masae Ikeda; Miwa Yasaka; Hiroko Machida; Masako Shida; Kenji Sato; Hiroshi Yoshida; Takeshi Hirasawa; Tadashi Imanishi; Mikio Mikami

doi:10.3390/cancers12092374

Cancers (Aug 2020)

Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer

Koji Matsuo,
Kazuhiro Tanabe,
Masaru Hayashi,
Masae Ikeda,
Miwa Yasaka,
Hiroko Machida,
Masako Shida,
Kenji Sato,
Hiroshi Yoshida,
Takeshi Hirasawa,
Tadashi Imanishi,
Mikio Mikami

Affiliations

Koji Matsuo: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA
Kazuhiro Tanabe: Medical Solution Promotion Department, LSI Medience Corporation, Tokyo 1748555, Japan
Masaru Hayashi: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Masae Ikeda: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Miwa Yasaka: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Hiroko Machida: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Masako Shida: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Kenji Sato: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Hiroshi Yoshida: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Takeshi Hirasawa: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan
Tadashi Imanishi: Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa 2591193, Japan
Mikio Mikami: Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 2591193, Japan

DOI: https://doi.org/10.3390/cancers12092374
Journal volume & issue: Vol. 12, no. 9
p. 2374

Abstract

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Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.

Published in Cancers

ISSN: 2072-6694 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.mdpi.com/journal/cancers/

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Abstract

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