INDICATORS OF CELLULAR AND HUMORAL TYPES OF THE IMMUNITY IN PATIENTS WITH RESPIRATORY ATOPY AND PSEUDOATOPY DEPENDING ON THE LEVEL OF INJURY OF RESPIRATORY TRACT

Abstract

The article provides study of the cellular and humoral links of immunity against atopy and respiratory pseudoatopy depending on the level of the lesion respiratory tract. In the structure of the pathology were: atopic rhinosinusitis (AR; n=28), atopic asthma (ABA; n=28), polypous rhinosinusitis (PRS; n=68), asthmatic triad (AT; n=28). The control– healthy people, n=219. Humoral link was investigated using flow cytometry, cell link and CIC – by enzyme immunoassay. Regardless of the genesis of allergic inflammation of the upper respiratory tract (PRS and AR), a high content of CD19+ cells relative to bronchial asthma, for bronchial asthma (AT and ABA) – CD8+ relative to control. For pseudoatopy (PRS and AT) reduced the concentration sIgA and С1q regarding atopy (AR and ABA). The content of sIgA relative to ABA was increased in the AR. AT is characterized by an increase in the number of CD3+, CD4+ and low amount of CD16+ relative to PRS.

Keywords

• клеточный иммунитет
• гуморальный иммунитет
• атопический риносинусит
• атопическая бронхиальная астма
• астматическая триада
• полипозный риносинусит