H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans

Kamila Delaney; Maude Strobino; Joanna M. Wenda; Andrzej Pankowski; Florian A. Steiner

doi:10.1038/s41467-019-10404-9

Nature Communications (Jun 2019)

H3.3K27M-induced chromatin changes drive ectopic replication through misregulation of the JNK pathway in C. elegans

Kamila Delaney,
Maude Strobino,
Joanna M. Wenda,
Andrzej Pankowski,
Florian A. Steiner

Affiliations

Kamila Delaney: Department of Molecular Biology and Institute for Genetics and Genomics in Geneva, University of Geneva
Maude Strobino: Department of Molecular Biology and Institute for Genetics and Genomics in Geneva, University of Geneva
Joanna M. Wenda: Department of Molecular Biology and Institute for Genetics and Genomics in Geneva, University of Geneva
Andrzej Pankowski: Team of Mathematics and Physics, Faculty of Civil Engineering, Mechanics and Petrochemistry, Warsaw University of Technology
Florian A. Steiner: Department of Molecular Biology and Institute for Genetics and Genomics in Geneva, University of Geneva

DOI: https://doi.org/10.1038/s41467-019-10404-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Substitution of lysine 27 with methionine in histone H3.3 (H3.3K27M) is a driver mutation of pediatric high-grade gliomas. Here the authors show that H3.3K27M-mediated alterations in H3K27me3 distribution result in ectopic DNA replication and cell cycle progression of germ cells in Caenorhabditis elegans, through JNK pathway misregulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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